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A pleated filter cartridge comprising a hydrophilic organic polymeric microporous filter membrane having a preformed substantially non-porous sealing area and a filter housing having, preferably, a hydrophobic thermoplastic sealing surface in thermoplastic sealing relationship with the sealing area. Preferably, the pleated filter cartridge is a pleated cylindrical membrane and the housing includes endcaps thereto.

The preferred pleated cylindrical filter is produced from an elongated porous filtration area longitudinally bordered by substantially non-porous sealing areas. Such a membrane may be produced by a specific casting method or collapsing the pores along the longitudinal borders of the filtration area. The filter element is particularly useful for the filtration of aqueous liquids, particularly parenteral or body liquids.

(a) an end cap having hydrophobic thermoplastic sealing material therein;

(b) a hydrophilic microporous membrane in sheet form having a microporous filtering surface and nonporous crushed border surface with substantially closed micropores;

(c) the nonporous border surface partially inserted and thermoplastically sealed within the hydrophobic thermoplastic sealing material of the end cap, wherein no portion of the microporous filtering surface contacts the hydrophobic thermoplastic sealing material.

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